Endocrine Abstracts

: Sebaceous glands are very sensitive to androgens which can modify the size but not the number of sebaceous glands. Sebaceous hyperplasia is a common benign proliferation of the sebaceous glands seen during the first weeks of life, being reported in 89.4% of 1000 newborns enrolled in across-sectional prospective study in the period of November 2007 to May 2009 in India [1] or in 35% of 2938 neonates aged up to three days of life hospitalized in a Brazilian city [2]. Sebum sec...

Aim: The aim of the study was to evaluate the relation of vitiligo with thyroid autoimmunity.Materials and methods: A cross sectional study was done on 75 patients clinically diagnosed (old and new) with different types of vitiligo. Patients with known thyroid disease were excluded from the study. Serum TSH and anti-TPO antibodies were measured in all patients.Results: The prevalence of anti-TPO antibody positivity was found in 23 ...

Introduction: Psoriasis is not only a skin disease, is a chronic inflammatory disease associated with serious comorbidities: psoriatic arthritis, metabolic syndrome (obesity, dyslipidemia and insulin resistance), Crohn’s disease, depression, ocular problems, cardio-vascular diseases (myocardial infarction), cancer.Methods: 1236 patients (male 54.13% and female 45.87%) with psoriasis were seen in an Outpatient Clinic over a period of 8 years (2004&#1...

We describe a case of subacute thyroiditis in a psoriatic patient treated with Adalimumab, with a very good clinical evolution with nonsteroidal anti-inflamatory medication.Tumor necrosis factor alpha (TNF-α) is a pleiotropic cytokine produced by a variety of cells, comprehending T lymphocytes. TNF-α mediates its effects through two receptors, known as p55 (TNF-R1), and p75 (TNF-R2). TNF-α plays a primary role in both the induction and the...

A broad spectrum of cutaneous disorders may be diagnosed in patients with type 1 and type 2 diabetes mellitus. Some of dermatologic lesions may precede any clinical or biochemical evidence for diabetes, while others are considered well known complications of the metabolic disorder. We highlight typical, rare dermatological manifestations of diabetes, excluding infectious, disorders related to complications of diabetes mellitus and skin conditions induced by treatment of diabet...

Ganuloma annulare (GA) is a self-limited inflammatory dermatosis, clinically characterized by the presence of papules arranged in annular or circinate pattern, mostly on the extremities. GA has rarely been reported in childhood, although is a not a rare condition seen in adulthood. Aetiology and pathogenesis of GA are still unknown, although variable associations have been reported, during last decades, with diabetes mellitus, thyroid disorders, HIV infection, malignancies, tu...

Erosio interdigitalis blastomycetica is a special form candidiasis commonly seen in the third web space of digits, but can spread to all web spaces. Diagnosis is clinically suspected in the presence of maceration and ulceration, erythema, sometimes associated with pain. The main predisposing condition is chronic maceration (for example in launderers), irritant chronic agents and prolonged moisture affect skin barrier with subsequent colonization of Candida spp. Direct...

Differentiated thyroid cancers include papillary, follicular carcinomas and are usually associated with a good prognosis. Up to 10% of patients develop metastatic lessions and radioiodine resistance. Tirosine kinase inhibitors (TKI) represent a strong therapeutic option for patients with advanced metastatic disease and radioiodine resistance. Sorafenib is the only TKI approved for the treatment of locally advanced or metastatic differentiated radioiodine resistant thyroid carc...

Guidelines recommend hormonal treatment in severe acne, in forms of acne with no response to standard therapeutical options, in women with proved hyperandrogenism. Hormonal therapy for acne includes oral contraceptives; anti-androgens, such as cyproterone acetate, spironolactone and flutamide; low-dose glucocorticoids and gonadotropin-releasing hormone agonists.In daily practice there are many cases with moderate to severe forms of acne, in young women w...

Case report: A 52-year-old woman had an appointment at the dermatology department for a previous diagnosis of melasma. She was seen in October and her pigmentation had appeared somewhere during summer. She did not recall any drug intake, she denied sun exposure in the recent past, and she was a social employee working indoor.At the clinical examination intense hyperpigmentation around the eyes was noted. In contrast with the rest of the skin of normal as...